Chemical Structure and Cytotoxicity of Ganodermanondiol Isolated from Ganoderma lucidum on B16F10 Melanoma Cells Previous studies of G. lucidum have established that it contains more than 300 biologically active compounds such as triterpenoids, polysaccharides, and steroids. Initially, the ethanol (EtOH) extract of dried G. lucidum was suspended in water and partitioned successively with ethyl acetate (EtOAc). Using bioassay-guided fractionation, the [...]

Ganoderma lucidum against Enterovirus 71 (EV71) Since 1969, "the same year in which the infection of human enterovirus 71 (EV71) infection was identified for the first time", the infection mechanism has not been fully understood. However, this viral infection was associated with several clinical diseases, ranging from neurological disorders to hand–foot–mouth disease (HFMD), and is considered a [...]

In recent years, traditional herbal medicines have gained more interest as a complementary and alternative approach to cancer therapy because of their insignificant side effects on the human body. Ganoderma lucidum (GL), an important natural product derived from the medicinal mushroom, draws attention since it enhances human health and increases longevity. It has exhibited significant antitumor [...]

1. Immunomodulatory effect Host immune surveillance plays a crucial role in recognizing and destroying invading pathogens and host cells that become cancerous, so immunotherapy has become one of the important strategies for cancer prevention and treatment. Accumulating evidence implicates that G. lucidum polysaccharides(GLP) partially exert the anticancer action by stimulating the immune function. This is primarily attributed [...]