Lung cancer is the leading cause of cancer-related death worldwide. In contrast, the 5-year relative survival rate for all stages of lung cancer is approximately 21%, with the major histological subtype being non-small-cell lung cancer (NSCLC). The gold standard for NSCLC treatment remains the cisplatin-based chemotherapy regimen. However, prolonged use of chemotherapeutic agents might increase toxicities [...]
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal bone marrow stem cell disorders characterized by ineffective erythropoiesis with dysplastic bone marrow leading to peripheral blood cytopenias a variable propensity for progression to acute myelogenous leukemia (AML). Neutropenia occurs in 50 % of newly diagnosed patients, more frequently in those with higher-risk (70–80 %) than lower-risk [...]
Parkinson's disease (PD) is a neurodegenerative disease with an estimated 2–3% prevalence in the population above 65 years of age. The prevalence increases with age, from 1% at age 45–55 to 4% (men) and 2% (women) at age 85. Typical examples are the motor symptoms related to (nonreversible) loss of dopaminergic cells in the substantia nigra. [...]