Reishi Archives

Anticancer Effect of Ganoderma lucidum on Human Osteosarcoma Cells

By admin|2022-01-05T09:33:26+00:00January 5th, 2022|Categories: Reishi|Tags: anticancerganoderma, antitumorreishi|

Our study shows that Ganoderma lucidum/reishi/lingzhi shows antitumor properties on osteosarcoma cells in vitro. It was found that Ganoderma lucidum inhibits breast cancer cell growth and migration by suppressing Wnt/β-catenin signaling. It suppresses lung cancer through disruption of focal adhesions and induction of MDM2-mediated Slug degradation. Ganoderma lucidum inhibits breast cancer via downregulating the PI3K/AKT/mTOR pathway, [...]

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Anticancer and Anti-Inflammatory Benefits of Ganoderma lucidum on Melanoma and Breast Cancer Treatment

By admin|2021-12-23T09:41:05+00:00December 23rd, 2021|Categories: Reishi|Tags: breastcancerganoderma, ganodermalucidumanticancer, ganodermalucidumcancertreatment, Melanomacancerganoderma|

Ganoderma lucidum is also called “lingzhi” in China, and it has been used in China for the promotion of health and longevity for centuries. Numerous pharmacological effects associated with lingzhi have been recorded, among which are immunomodulatory, anti-inflammatory, antiviral, antioxidative, antiaging and antitumor properties. Studies have shown that Ganoderma lucidum contains a wide range of bioactive compounds associated with the promotion [...]

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Bioactivity of Ganoderma lucidum Triterpenes

By admin|2021-12-01T08:46:16+00:00December 1st, 2021|Categories: Reishi|Tags: ganodericacids, ganodermatriterpenoidsactivity, reishitriterpenoidsactivity|

As a species of pharmaceutical substances, triterpenes contribute to the health benefits of Ganoderma lucidum. Its commercial products include ganoderma lucidum spore oil softgel (reishi spore oil softgel), reishi spore powder. It has been proven that many of these triterpenoids, especially the ganoderic acids (GAs), are bioactive components responsible for several beneficial effects, including anti-inflammatory, anti-tumorigenic, [...]

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Major Bioactive Components in Reishi (Ganoderma lucidum) with Anti-aging Effects

By admin|2022-07-14T08:42:35+00:00November 29th, 2021|Categories: Reishi|Tags: reishiGanodermapeptides, reishiGanodermapolysaccharides, reishiGanodermatriterpenes|

The bioactive components in reishi (Ganoderma lucidum) that adjust their anti-aging functions mainly include polysaccharides, triterpenes, peptides, and polysaccharide peptides. Polysaccharides are the most important contributors to the bioactivity and medical application of Ganoderma lucidum, which are well known for their antioxidant and immunomodulatory properties. The structure of Ganoderma lucidum polysaccharides is made up of glucose, mannose, [...]

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Adverse Effects of Ganoderma Lucidum

By admin|2021-10-20T11:55:03+00:00October 20th, 2021|Categories: Reishi|Tags: AdverseEffectsGanoderma, AdverseEffectslingzhi, AdverseEffectsreishi|

As a well known herb, Ganoderma lucidum is regarded as safe and is listed in the safest drug class in the American Herbal Products Association Botanical Safety Handbook with no reported herb-drug interactions. Recent human clinical trials with Ganoderma lucidum have included laboratory safety parameters such as hepatic, renal, and hematological biomarkers and no pathological abnormality or serious adverse event [...]

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Anti-inflammatory Effects of Ganoderma Lucidum

By admin|2021-10-19T11:59:43+00:00October 19th, 2021|Categories: Reishi|Tags: Anti-inflammationGanoderma, Anti-inflammatoryGanoderma|

Inflammation is a physiological response to harmful stimuli that are physical, chemical, or biological in nature. A number of inflammatory markers, such as high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-1, and tumour necrosis factor (TNF)-α, have been shown to be associated with obesity, metabolic syndrome, and an elevated risk of chronic diseases. Elevated circulating levels of [...]

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Hypoglycaemic Activity of Ganoderma Polysaccharides and Proteins

By admin|2021-10-18T14:24:33+00:00October 18th, 2021|Categories: Reishi|Tags: Ganodermapolysaccharidesproteins, HypoglycaemicGanodermapolysaccharidesproteinsteins|

Hypoglycaemic activity of Ganoderma polysaccharides Hypoglycaemic effects of polysaccharides from Ganoderma lucidum have been exhibited in several in vitro and in vivo studies. Ganoderma polysaccharides showed a protective effect against alloxan-induced damage to pancreatic islets in vitro. Pre-treatment with intragastric Ganoderma polysaccharides (50-200mg/kg) for 10days produced hypoglycaemic effects via its scavenging ability to protect the pancreatic β-cells from alloxan-induced necrosis. Ganoderma polysaccharides (25-100mg/kg) given by single intraperitoneal injections to normal fasted mice reduced [...]

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Effects of Ganoderma Lucidum on Dyslipidaemia

By admin|2021-10-17T11:45:44+00:00October 17th, 2021|Categories: Reishi|Tags: GanodermaLucidumDyslipidaemia, lingzhiDyslipidaemia, reishiDyslipidaemia|

Dyslipidaemia which is characterised by decreased levels of HDL-C and accompanied with increased levels of TG, apo B, and small dense LDL particles, is an important modifiable risk factor for the development of atherosclerosis and CVD. Guidelines for the treatment of lipid disorders recommend initiating treatment with the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins. In [...]

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Hypoglycaemic activity of Ganoderma triterpenoids proteoglycans

By admin|2021-10-16T11:37:05+00:00October 16th, 2021|Categories: Reishi|Tags: Hypoglycaemicganodermatriterpenoids, Hypoglycaemiclingzhitriterpenoids, Hypoglycaemicreishitriterpenoids|

Hypoglycaemic activity of Ganoderma triterpenoids A series of in vitro studies have showed that Ganoderma lucidum (fruiting bodies) extract, including reishi spore oil and reishi spore powder, has a strong inhibitory effect on human aldose reductase activity. Ganoderic acid Df, a lanostane-type triterpenoid, exhibited potent aldose reductase inhibitory activity with an IC50 value of 22.8µM. It was subsequently demonstrated that ganoderol B, which was isolated [...]

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Antihypertensive effects of ganoderma lucidum

By admin|2021-10-15T13:00:56+00:00October 15th, 2021|Categories: Reishi|Tags: Antihypertensiveganodermalucidum, highpressureganoderma, highpressurereishi, polysaccharideshighpressure|

The latest guidelines for the hypertension(high pressure) management recommend initiating antihypertensive drug therapy in most patients with a combination of two different drugs from the classes of thiazide diuretics, calcium channel blockers, angiotensin converting enzyme (ACE) inhibitors, or angiotensin receptor blocker (ARBs). Ganoderma lucidum triterpenes and proteins have been demonstrated to possess potent ACE-inhibitory properties in vitro. It showed that the protein [...]

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