Breast cancer, the most common cancer in women worldwide, is a heterogeneous disease composed of a broad spectrum of tumor subtypes with different biological characteristics and clinical behavior. The primary breast cancer markers traditionally used in routine clinical practice to establish the diagnosis, prognosis, and therapy of the disease are estrogen receptor (ER), progesterone receptor (PR), [...]
Several biological activities relevant to caries prevention have been identified through various in vitro and in vivo studies. These include induction of the detachment of cariogenic microorganisms from hydroxyapatite, changes in cell surface hydrophobicity, bactericidal activity against cariogenic organisms, and the disruption of signal transduction in Streptococcus mutans. Glucan is one of the major components of [...]
Alcoholic beverages are commonly consumed by adults and food worldwide and are enjoyed because alcohol stimulates our appetite and makes meals more delicious. However, excessive intake increases the risk of various diseases. Vegetable and fruit consumption reduces the risk of alcohol-induced gastric cancer, suggesting that food components may affect the absorption and metabolism of ethanol. Therefore, [...]
Agaricus blazei, also known as God's mushroom, Mushroom of life, Royal Sun Agaricus, Mushroom of the Sun, or Almond mushroom. This is an edible mushroom with identified beneficial health effects, like preventing diabetes, hyperlipidemia, arteriosclerosis, and chronic hepatitis. Agaricus blazei is vastly used in traditional medicine as a medicinal extract for the prevention and treatment of cancer, as [...]
Medicinal mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum. In Asian countries, it is a nutraceutical whose regular consumption provides vitality and improves health. Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative, and antidiabetic [...]
Hippophae rhamnoides, also known as sea buckthorn, is a good plant, as it is a rich source of valuable bioactive components. Several studies have investigated its broad biological properties, and its uses range from the medical and cosmetic fields to the industrial food sector. The whole plant is rich in bioactive antioxidant and immunomodulating compounds, and hippophae rhamnoides berries, leaves, [...]
Obesity is the accumulation of excess fatty tissue, accompanying the increase of body weight and fat deposition in the liver, causing corresponding metabolism dysfunction. Evidence showed that consuming foods rich in bioactive compounds, such as fruits and vegetables, could benefit anti-obesity and obesity-association metabolism diseases. Our study showed that daily supplementation with seabuckthorn freeze-dried powder at [...]
Myofibroblasts are clinically and biologically important pathological features of pulmonary fibrosis, and their numbers on surgical lung biopsy directly correlate with progressive physiological deterioration and shortened survival. Although resident fibroblasts activate myofibroblasts in response to injury, their origin in lung fibrosis remains controversial. AECs gradually lose their epithelial cell markers and polarity during human lung fibrogenesis. [...]
We comprehensively analyze the effect of sea buckthorn (Hippophaes rhamnoides) on glucose homeostasis on central regulatory steps of postprandial glucose metabolism. Various biological models were utilized as complementary systems, including human cell lines, non‐vertebrate organisms, and the chick embryo model. Sea buckthorn is a rich source of biologically active compounds that benefit human health. In particular, [...]
Chemical Structure and Cytotoxicity of Ganodermanondiol Isolated from Ganoderma lucidum on B16F10 Melanoma Cells Previous studies of G. lucidum have established that it contains more than 300 biologically active compounds such as triterpenoids, polysaccharides, and steroids. Initially, the ethanol (EtOH) extract of dried G. lucidum was suspended in water and partitioned successively with ethyl acetate (EtOAc). Using bioassay-guided fractionation, the [...]