Effect of sea buckthorn oil on 3T3-L1 pre-adipocytes proliferation Cytotoxicity is one key indicator in evaluating the effects of a particular chemical compound on a given cell line. In our study, the Lactate dehydrogenase (LDH) assay was employed to determine the cytotoxicity of sea buckthorn oil on 3T3-L1 preadipocytes. The addition of sea buckthorn oil at [...]
Ganoderma lucidum against Enterovirus 71 (EV71) Since 1969, "the same year in which the infection of human enterovirus 71 (EV71) infection was identified for the first time", the infection mechanism has not been fully understood. However, this viral infection was associated with several clinical diseases, ranging from neurological disorders to hand–foot–mouth disease (HFMD), and is considered a [...]
As the major components of the outer skin layer are lipids, we can infer that using lipid derivatives will enhance skin conditions. Therefore, plant oils can be used as a source of compounds that may protect skin cells due to their multidirectional activities, including anti-inflammatory, antibacterial, and antioxidants, as well as the source of fatty acids. [...]
Chronic obstructive pulmonary disease (COPD) is caused by the prolonged inhalation of toxic gases, primarily cigarette smoke. Cigarette smoke contains many harmful substances, such as oxidants. It has been hypothesized that the etiology of COPD stems from an oxidant-antioxidant imbalance and a protease–antiprotease imbalance. Oxidative stress is an important factor in COPD pathogenesis. Therefore, antioxidant treatment [...]
Due to its various biological activities, astaxanthin has been used to prevent and treat various systemic diseases in vivo. In recent years, researchers have confirmed that astaxanthin is important in preventing acute liver injury, alleviating insulin resistance and NAFLD, liver fibrosis, and liver cancer. Liver Fibrosis Liver fibrosis is a key link in chronic liver diseases [...]
The bioactive components in Ganoderma lucidum that mediate their anti-aging or anti-aging-related functions mainly include polysaccharides, triterpenes, peptides, and polysaccharide peptides. We will first outline their general characteristics and describe their lifespan extension and related effects. Polysaccharides are the most important contributors to the bioactivity and medical application of Ganoderma lucidum. It has been reported that these [...]
A persistent hyperglycemic environment enhances the protein glycation reaction and increases advanced glycation end products (AGEs), which can stimulate the production of reactive oxygen species (ROS). Accumulated ROS induces oxidative stress and inflammation and activates various signaling pathways, such as mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathway, which aggravate oxidative stress and inflammation. Besides, [...]
In recent years, traditional herbal medicines have gained more interest as a complementary and alternative approach to cancer therapy because of their insignificant side effects on the human body. Ganoderma lucidum (GL), an important natural product derived from the medicinal mushroom, draws attention since it enhances human health and increases longevity. It has exhibited significant antitumor [...]
1. Immunomodulatory effect Host immune surveillance plays a crucial role in recognizing and destroying invading pathogens and host cells that become cancerous, so immunotherapy has become one of the important strategies for cancer prevention and treatment. Accumulating evidence implicates that G. lucidum polysaccharides(GLP) partially exert the anticancer action by stimulating the immune function. This is primarily attributed [...]
Breast cancer, the most common cancer in women worldwide, is a heterogeneous disease composed of a broad spectrum of tumor subtypes with different biological characteristics and clinical behavior. The primary breast cancer markers traditionally used in routine clinical practice to establish the disease's diagnosis, prognosis, and therapy are estrogen receptor (ER), progesterone receptor (PR), and human [...]