There is some evidence that organic germanium may improve circulation. A study published in the journal "Life Sciences" found that germanium supplementation increased the deformability of red blood cells, which can help to improve blood flow. The study also found that germanium supplementation increased nitric oxide production, a gas that relaxes blood vessels and improves blood [...]

There is some evidence that organic germanium may reduce pain. A study published in the journal "Phytotherapy Research" found that germanium supplementation reduced pain in people with osteoarthritis. The study found that germanium supplementation reduced the severity of pain, the number of days with pain, and the need for pain medication. Another study, published in the [...]

There is some evidence to suggest that organic germanium may improve wound healing. A 2014 study published in the journal "Wound Repair and Regeneration" found that topical application of organic germanium accelerated the healing of chronic wounds in rats. The study found that germanium helped to increase blood flow to the wound site, which promoted the [...]

There is some evidence to suggest that organic germanium may increase energy levels. A 2011 study published in the journal "Evidence-Based Complementary and Alternative Medicine" found that oral supplementation with organic germanium improved energy levels in people with chronic fatigue syndrome. The study found that germanium helped to increase the production of ATP, the body's primary [...]

There is some evidence to suggest that organic germanium may improve mental function. A 2012 study published in the journal "Nutritional Neuroscience" found that oral supplementation with organic germanium enhanced cognitive function in people with Alzheimer's disease. The study found that germanium helped increase blood flow to the brain, promoting new neuron growth. Additionally, germanium helps [...]

Antitumor Effects Over the past 30 years, previous studies have strongly suggested three possible ways by which G. frondosa exerts its anticancer effect—protection of healthy cells, prevention of tumor metastasis, and inhibition of tumor growth. In other words, G. frondosa can fight against tumors directly and indirectly via enhancement of the immune system. The antitumor activity [...]

Polysaccharides In the past 30 years, over 47 bioactive polysaccharide fractions have been isolated and purified from the fruiting body, mycelium, and cultured medium of G. frondosa using different extraction methods. G. frondosa contains 3.8% water-soluble polysaccharides on a dry weight basis, of which 13.2% was (1→3, 1→6)-β-D-glucan, and others include heteroglycan or the heteroglycan/protein complex. Among [...]

A persistent hyperglycemic environment enhances the protein glycation reaction and increases advanced glycation end products (AGEs), which can stimulate the production of reactive oxygen species (ROS). Accumulated ROS induces oxidative stress and inflammation and activates various signaling pathways, such as mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) pathway, which aggravate oxidative stress and inflammation. Besides, [...]