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As part of traditional Chinese medication regimens, cordyceps extract has previously been shown to ameliorate various diseases, including metabolic anomalies. However, it needs to be clarified what the bioactive ingredient in cordyceps extracts is and the molecular mechanisms through which these extracts elicit beneficial effects. Here we demonstrate that myriocin, a pharmacological inhibitor of ceramide biosynthesis in [...]

Breast cancer, the most common cancer in women worldwide, is a heterogeneous disease composed of a broad spectrum of tumor subtypes with different biological characteristics and clinical behavior. The primary breast cancer markers traditionally used in routine clinical practice to establish the diagnosis, prognosis, and therapy of the disease are estrogen receptor (ER), progesterone receptor (PR), [...]

Several biological activities relevant to caries prevention have been identified through various in vitro and in vivo studies. These include induction of the detachment of cariogenic microorganisms from hydroxyapatite, changes in cell surface hydrophobicity, bactericidal activity against cariogenic organisms, and the disruption of signal transduction in Streptococcus mutans. Glucan is one of the major components of [...]

Alcoholic beverages are commonly consumed by adults and food worldwide and are enjoyed because alcohol stimulates our appetite and makes meals more delicious. However, excessive intake increases the risk of various diseases. Vegetable and fruit consumption reduces the risk of alcohol-induced gastric cancer, suggesting that food components may affect the absorption and metabolism of ethanol. Therefore, [...]

Agaricus blazei, also known as God's mushroom, Mushroom of life, Royal Sun Agaricus, Mushroom of the Sun, or Almond mushroom. This is an edible mushroom with identified beneficial health effects, like preventing diabetes, hyperlipidemia, arteriosclerosis, and chronic hepatitis. Agaricus blazei is vastly used in traditional medicine as a medicinal extract for the prevention and treatment of cancer, as [...]