Agaricus blazei, also known as God's mushroom, Mushroom of life, Royal Sun Agaricus, Mushroom of the Sun, or Almond mushroom. This is an edible mushroom with identified beneficial health effects, like preventing diabetes, hyperlipidemia, arteriosclerosis, and chronic hepatitis. Agaricus blazei is vastly used in traditional medicine as a medicinal extract for the prevention and treatment of cancer, as [...]
Medicinal mushrooms are rich sources of pharmacologically active compounds. One of the mushrooms commonly used in traditional Chinese medicine is Ganoderma lucidum. In Asian countries, it is a nutraceutical whose regular consumption provides vitality and improves health. Ganoderma lucidum is an important source of biologically active compounds. The pharmacologically active fraction of polysaccharides has antioxidant, immunomodulatory, antineurodegenerative, and antidiabetic [...]
Hippophae rhamnoides, also known as sea buckthorn, is a good plant, as it is a rich source of valuable bioactive components. Several studies have investigated its broad biological properties, and its uses range from the medical and cosmetic fields to the industrial food sector. The whole plant is rich in bioactive antioxidant and immunomodulating compounds, and hippophae rhamnoides berries, leaves, [...]
Obesity is the accumulation of excess fatty tissue, accompanying the increase of body weight and fat deposition in the liver, causing corresponding metabolism dysfunction. Evidence showed that consuming foods rich in bioactive compounds, such as fruits and vegetables, could benefit anti-obesity and obesity-association metabolism diseases. Our study showed that daily supplementation with seabuckthorn freeze-dried powder at [...]
Myofibroblasts are clinically and biologically important pathological features of pulmonary fibrosis, and their numbers on surgical lung biopsy directly correlate with progressive physiological deterioration and shortened survival. Although resident fibroblasts activate myofibroblasts in response to injury, their origin in lung fibrosis remains controversial. AECs gradually lose their epithelial cell markers and polarity during human lung fibrogenesis. [...]
We comprehensively analyze the effect of sea buckthorn (Hippophaes rhamnoides) on glucose homeostasis on central regulatory steps of postprandial glucose metabolism. Various biological models were utilized as complementary systems, including human cell lines, non‐vertebrate organisms, and the chick embryo model. Sea buckthorn is a rich source of biologically active compounds that benefit human health. In particular, [...]
Chemical Structure and Cytotoxicity of Ganodermanondiol Isolated from Ganoderma lucidum on B16F10 Melanoma Cells Previous studies of G. lucidum have established that it contains more than 300 biologically active compounds such as triterpenoids, polysaccharides, and steroids. Initially, the ethanol (EtOH) extract of dried G. lucidum was suspended in water and partitioned successively with ethyl acetate (EtOAc). Using bioassay-guided fractionation, the [...]
There have been numerous studies concerning the beneficial effects of astaxanthin. Astaxanthin-mediated neuroprotection in experimental models of neurological disorders involves anti-oxidation, anti-inflammation, and anti-apoptotic mechanisms. The following sections will delve into these molecular mechanisms and their potential as treatments for neurological diseases. Anti-Oxidant Effects Oxidative stress is a key mediator in the pathology of neurological diseases. [...]
Antitumor Effects Over the past 30 years, previous studies have strongly suggested three possible ways by which G. frondosa exerts its anticancer effect—protection of healthy cells, prevention of tumor metastasis, and inhibition of tumor growth. In other words, G. frondosa can fight against tumors directly and indirectly via enhancement of the immune system. The antitumor activity [...]
Polysaccharides In the past 30 years, over 47 bioactive polysaccharide fractions have been isolated and purified from the fruiting body, mycelium, and cultured medium of G. frondosa using different extraction methods. G. frondosa contains 3.8% water-soluble polysaccharides on a dry weight basis, of which 13.2% was (1→3, 1→6)-β-D-glucan, and others include heteroglycan or the heteroglycan/protein complex. Among [...]