170 traditional Chinese medicines contain chlorogenic acid, all of the medicines have the therapeutic effects of clearing heat, detoxification, antibacterial and anti-inflammation. Chlorogenic acid is called “the seventh nutrient” and is widely used in health care industry. The main functions of chlorogenic acid include:
Bioactivity
Chlorogenic acid has a wide range of bioactivities. Many science researches on the bioactivity of chlorogenic acid have been carried out in fields such as food, health care, medicine and daily-use chemical industry. Chlorogenic acid is an important biologically active substance, which has antibacterial, antiviral, leucocyte increasing, liver protection, anti-tumor, lowering blood pressure, lowering blood lipids, scavenging free radicals and improving the central nervous system.
Antioxidation
Chlorogenic acid is a potent phenolic antioxidant with stronger antioxidant ability than caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butylhydroxyanisole (BHA) and tocopherol. Chlorogenic acid has anti-oxidation effect because it contains a certain amount of R-OH groups, which can form hydrogen radicals with anti-oxidation effect to eliminate the activity of free radicals such as hydroxyl radicals and superoxide anions, thus protect the tissue from oxidation damage.
Scavenging Free Radicals, Anti-aging, Anti-musculoskeletal Aging
Chlorogenic acid and its derivatives have stronger free radical scavenging effect than ascorbic acid, caffeic acid and tocopherol, and can effectively eliminate DPPH radicals, hydroxyl radicals and superoxide anion radicals, and can also inhibit low density lipoprotein oxidation. Chlorogenic acid plays an important role in effectively eliminating free radicals in the body, maintaining the normal structure and function of body cells, and preventing and delaying the occurrence of tumor mutations. Chlorogenic acid promotes the synthesis and decomposition of collagen in the skin, bones, and muscles of human body. It has the functions of promoting metabolism and preventing decline. It can be used to prevent astronomers from deteriorating bones and muscles caused by weightlessness in space.
Inhibition of Mutations and Anti-tumor
Pharmacological experiments have proven that chlorogenic acid has anti-cancer and anti-cancer effects. Japanese scholars have found that this effect is related to chlorogenic acid and other anti-mutagenic components, revealing the significance of chlorogenic acid for tumor prevention.
Polyphenols in vegetables and fruits, such as chlorogenic acid, caffeic acid, etc., can inhibit the variability of the carcinogens aflatoxin B1 and Benzo(a)pyrene by inhibiting activated enzymes; chlorogenic acid can also reduce carcinogenicity by the utilization and transportation in liver to achieve anti-cancer effect. Chlorogenic acid has significant inhibitory effect on colorectal cancer, liver cancer, and laryngeal cancer.
Cardiovascular Protection
As a free radical scavenger and antioxidant, chlorogenic acid has been proved by a large number of experiments, this bioactivity of chlorogenic acid can produce a protective effect on the cardiovascular system. Isochlorogenic acid B has a strong promotion of pre-chlorogenic acid B in rats, which also has a stronger effect on the release of prostacyclin (PGI2) and antiplatelet aggregation in rats; Isochlorogenic acid C also promotes the release of PGI2. In addition, isochlorogenic acid B has a strong inhibitory effect on the biosynthesis of platelet acrosin and the non-induced endothelin damage induced by hydrogen peroxide.
Antihypertensive Effect
Many years of clinical trials confirmed that chlorogenic acid has a significant antihypertensive effect, and the efficacy is stable, non-toxic, no side effects.
Other Bioactivities
Since chlorogenic acid has a specific inhibitory effect on HAase and Gl-6-Pase, chlorogenic acid cures wounds, moisturizes skin, lubricates joints, prevents inflammation, and controls the balance of blood glucose in the body. also has a strong inhibitory and killing effect on various diseases and viruses. Chlorogenic acid has the effects of lowering blood pressure, antibacterial, anti-virus, anti-inflammatory, leucocyte increasing, diabetes prevention, significantly increases gastrointestinal motility and promotes the secretion of gastric juice. Chlorogenic acid has a significant effect on acute throat inflammation. Studies have shown that oral administration of chlorogenic acid can significantly stimulate the secretion of bile, with the efficacy of gallbladder and liver protection; it can also effectively inhibit H2O2-induced red blood cells hemolysis in rats.