General Details
Product name: Radix Isatidis Extract.
Plant Latin name: Isatis tinctoria L. or Isatis indigotica Fort. or Baphicacanthus cusia (Nees) Brem.
Product specifications: (R,S)-Goitrin; DL-Goitrin 0.05% 1.5% 2% 98% HPLC.
Appearance: Brown powder.
The main components of Radix Isatidis extract include indigoside, indigo, indigo, isatis B, uridine, uracil, hypoxanthine, salicylic acid, indigo ketone, carotene, β-sitosterol, isatis B, isatis C, and D, etc. In addition, Radix Isatidis extract also contains plant protein, resin, sugar, sinigrin, various amino acids, and trace elements.
Health benefits
The main functions of Radix Isatidis extract include antiviral, antibacterial, anti-inflammatory, immunomodulatory, heat-clearing, and detoxification.
Antiviral effect
Radix Isatidis extract has an inhibitory effect on various viruses, including influenza virus, respiratory syncytial virus, etc. It can alleviate the symptoms caused by viral infection by inhibiting the replication and spread of viruses. In addition, Radix Isatidis also has a good inhibitory and killing effect on influenza viruses, porcine parvovirus, porcine reproductive and respiratory syndrome viruses, etc. at the in vitro cell level.
Radix Isatidis Extract
Antibacterial effect
Radix Isatidis extract has an inhibitory effect on a variety of bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Salmonella typhi, Salmonella paratyphi, Shigella dysenteriae, etc. Its water extract inhibits streptococci, Escherichia coli, Staphylococcus aureus, and other common bacteria in pig farming clinics.
Anti-inflammatory effect
Radix Isatidis extract can reduce inflammatory reactions and relieve symptoms such as fever, cough, and sore throat. It may exert anti-inflammatory effects by inhibiting the release of inflammatory mediators.
Immunomodulatory effect
Isatis root extract can regulate the function of the immune system and enhance the body’s resistance. It may promote the activity of immune cells and increase the level of immunoglobulins, thereby helping the body resist the invasion of pathogens. In addition, the main components of Isatis root, such as Isatis polysaccharides, can improve the specific and nonspecific immunity of animal bodies.
Heat-clearing and detoxifying effect
Isatis root has the effect of clearing heat and detoxifying and can be used to treat heat-toxic diseases, such as sore throat, mouth sores, carbuncle, sore, etc. Its extract may also play a similar role in this regard.
Benefits of Goitrin in Radix Isatidis Extract
Antiviral effect
Inhibit the activation of viral infection mechanism: Goitrin can affect the initial infection link of virus adsorption and entry into host cells. For example, the influenza virus can change the structure or properties of some receptors on the surface of host cells, making it difficult for the influenza virus to accurately identify and bind to cells. Thus, it blocks the process of successful virus invasion into cells, inhibits the occurrence of viral infection from the source, and has potential application value in the prevention of influenza.
Interfere with virus replication in cells: When some viruses break through the cell defense line and enter the host cell, Goitrin can interfere with the viral genome replication and subsequent assembly of new virus particles by acting on the viral nucleic acid synthesis process or related replication enzymes and other key links, so that the virus cannot reproduce in large quantities, thereby reducing the body damage caused by a viral infection, helping to alleviate symptoms after infection and shorten the course of the disease, such as playing a positive role in dealing with some common respiratory viral infections.
Antibacterial effect
Inhibit bacterial growth and metabolism: Goitrin has an inhibitory effect on some common pathogenic bacteria, such as Staphylococcus aureus and Escherichia coli. It may affect the synthesis of bacterial cell walls or interfere with the metabolic pathways inside bacteria, causing bacteria to be unable to grow and divide and reproduce normally, and ultimately inhibit bacterial proliferation. In treating inflammatory diseases caused by these bacterial infections, such as tonsillitis and enteritis, Goitrin can be used as a potential antibacterial ingredient to help improve the condition and reduce inflammatory symptoms.
Anti-inflammatory effect
Regulate the production and release of inflammatory factors: When an inflammatory reaction occurs in the body, a variety of inflammatory factors such as interleukin and tumor necrosis factor will be produced in the body, which will further aggravate the symptoms of redness, swelling, pain, etc. at the site of inflammation. Goitrin can regulate the production and release of inflammatory factors to maintain them at a relatively reasonable level, avoid excessive activation of inflammatory reactions, and thus reduce the damage caused by inflammation to local tissues, especially in diseases such as pharyngitis and respiratory inflammation, which helps to relieve discomfort symptoms such as sore throat.
Immunomodulatory effect
Enhance the activity of immune cells: Goitrin can activate the activity of immune cells such as macrophages and T lymphocytes. Macrophages play the role of “scavengers” in the body’s immune defense system. After being activated, they can more efficiently engulf and remove pathogens and some apoptotic cells and foreign bodies in the body; T lymphocytes play a key role in the specific immune response process. After their activity is enhanced, they can more accurately identify and kill cells infected by pathogens such as viruses and bacteria, enhance the body’s specific immune ability, and then enhance the body’s overall immune defense function, which helps the body better resist the invasion of external pathogens.
Antioxidant effect
Free radical scavenging: Goitrin has a certain antioxidant capacity and can scavenge excess free radicals in the body, such as superoxide anion free radicals and hydroxyl free radicals. If these free radicals accumulate in the body, they will attack biological macromolecules such as DNA, proteins, lipids, etc. in cells, causing cell damage, aging, and even disease. Goitrin reacts with free radicals through its chemical structure characteristics, converting them into relatively stable substances, reducing the harm of free radicals to the body, and playing a certain role in delaying aging and maintaining normal cell function.
Applications
Radix Isatidis Extract is widely used in pharmaceutical preparations, health care product raw materials, herbal tea beverage additives, health food additives, veterinary drug raw materials feed mixing, etc.