Nuciferine 1%, 2%, 3%, 6%, 98% HPLC
Product name: Lotus Leaf Extract
Plant latin name:Nelumbo Nucifera
Product specifications: Nuciferine 1%、2%、3%、6%、98% HPLC
Appearance: brownish yellow powder
CAS No.: 475-83-2
Molecular formula: C19H21NO2
Molecular weight: 295.376
1 Lowering Lipids
With obese hyperlipidemic rat model scientists observe the effect of lotus leaf extract total alkaloids on body weight, body fat and blood lipids, found that the total alkaloids of lotus leaf significantly inhibited the weight of obese rats, affecting their obesity levels, and can lower the serum total cholesterol(TC), triglyceride(TG) and atherosclerosis index(AI) of the rats, but also play a role in weight loss with no significant diarrhea and appetite suppression.
With acute hyperlipidemic mice model scientists observe the effect lotus leaf extract alkaloids on TC and TG, the results show that lotus alkaloids significantly inhibited the TG of acute hyperlipidemia in mice. It was also proved that it has lipid-lowering effect by feeding mice with lotus leaf extract (as alkaloids).
With type II diabetes rat model, scientists carried out lipid lowering experiment by feeding alkaloids (alcohol extraction), lotus leaf extract alkaloid salts (acid extraction). After comparing the level of serum triglyceride and cholesterol, the results showed that the effect of lotus leaf alkaloids salt group has stronger lipid-lowering effect than the lotus leaf alkaloid group.
Studies showed that lotus leaf extract has a significant lipid-lowering effect on human hyperlipidemia after treatment, the average serum level of TC, TG and LDL-C was significantly lower than before treatment, while HDL-C increased obviously. The results also showed that the lotus leaf extract treatment increased TC, TG ratio significantly, LDL-C, HDL-C ratio was obviously lower. At the same time, all the indexes of blood lipids all dropped to 58.07% after treatment, which is an acceptable range, which indicates that lotus leaf water extract has a comprehensive effect on the above blood lipid indexes and has a good lipid regulating effect.
2 Weight Loss
Lotus leaf extract contains a variety of alkaloids to breakdown fats. Lotus leaf can form a layer of fat isolation membrane in the human intestinal wall to prevent fat absorption and fat accumulation.
2.1 Promote intestinal peristalsis, excretion of toxins from the body
Lotus leaf contains a lot of fiber, which promotes the peristalsis of large intestine, helping toxins excretion. Lotus leaf is also helpful solving the constipation troubles, so the fat lower abdomen will slowly become flat.
2.2 Acting as a diuretic with slimming effect
Aromatic compounds in lotus leaves can effectively dissolve fat to prevent the accumulation of fat in the body; Vitamin B and vitamin C can promote gastric secretion, helping digestion.
2.3 Experimental Study
It has been proved by previous physicians that lotus leaves can be used to treat obesity, which can be used in the treatment of obesity due to impotence, simple obesity or obesity in patients with hyperlipidemia.
The results of related studies showed that 2.14~10.7 mg/kg of total alkaloids of lotus leaf could reduce the TC and TG of obese rats, significantly inhibit the weight of obese rats and, and there was dose-dependent, However, the effect on HDL-C was not obvious. When comparing the inhibition effect of crude leaf lotus extract(alkaloids) and Orlistat to pancreatic lipase, it showed that: Orlistat inhibition 71.58%, lotus leaf alkaloids 15.72%, which provided strong evidences for the development of lotus leaf alkaloids as diet pills.
3 Clinical Application
After treating 62 patients suffered from hyperlipidemia with lotus leaf extract capsules, the results showed that the levels of TC, TG and LDL-C in serum of lotus leaf group decreased significantly and the level of HDL-C increased greatly, which was significantly different from before treatment (0.01). Lotus leaf extract has good lipid-lowering effect on human body.