Ursolic Acid 25%, 80%, 90% , 98% HPLC
Product name: Loquat Leaf Extract
Plant latin name:Eriobotrya japonica (Thunb.) Lindl
Product specifications: Ursolic Acid 25%, 50%, 80% ,90%, 98% HPLC
Appearance: pale green to white powder
CAS No.: 77-52-1
Molecular formula: C30H48O3
Molecular weight: 456.68
Loquat leaf extract is rich in ursolic acid, which has many biological effects such as sedating, anti-inflammatory, anti-bacterial, anti-diabetic, anti-ulcer and lowering blood sugar. In 2011 it was found that ursolic acid induced F9 teratoma cell differentiation and anti-angiogenic effect. In addition, ursolic acid has obvious antioxidant functions, which is widely used in medicine and cosmetics.
Ursolic acid inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, also decreases proliferation of cancer cells and induce apoptosis. Ursolic acid has been proved to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation.
As an aromatase inhibitor, ursolic acid from loquat leaf extract can increase the amount of muscle and brown fat and decrease white fat obesity. Ursolic acid is able to reduce muscle atrophy and to stimulate muscular growth, it may be an option for potential cardioprotection.
Meanwhile studies have shown that loquat leaf extract improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways. Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in brain through suppressing p38/NF-κB mediated inflammatory pathways. loquat leaf extract boosts the cellular immune system and pancreatic beta-cell function in streptozotocin-induced by diabetes.