Product name: Dihydromyricetin
Plant latin name: Ampelopsis grossedentata(Hand.-Mazz.)
Product specification: Dihydromyricetin 10%，50%，90%，98% HPLC
Appearance: pale yellow to white crystals
CAS no.: 27200-12-0
Molecular formula: C15H12O8
Molecular weight: 320.25
Dihydromyricetin is the main active ingredient of ampelopsis grossedentata extract, which has the properties of scavenging free radicals, anti-oxidation, anti-thrombosis, anti-tumor, anti-inflammatory and other unique effects; dihydromyricetin also can prevent alcoholic liver and fatty liver, inhibit the deterioration of liver cells, reduce the incidence of liver cancer, inhibit platelet aggregation and in vivo thrombosis formation, lower blood lipids and blood glucose levels, improve SOD activity.
Antibacterial effect: Pharmacological experiments show that dihydromyricetin has antibacterial effects on bacillus subtilis, staphylococcus aureus, salmonella, escherichia coli, aerobacter aerogenes, brewer’s yeast, rhodotorula glutinis, penicillium, aspergillus niger, yellow aspergillus, mucor and rhizopus.
Blood glucose and blood lipid regulation: Pharmacological experiments showed that dihydromyricetin can significantly inhibit the raised blood sugar induced by alloxan, epinephrine and streptozotocin, increasing serum insulin levels, meanwhile Pancreatic tissue lymphocyte infiltration significantly decreased, inflammatory response was significantly reduced, the number of islets increased. Dihydromyricetin lowered serum triglyceride (TG) content of streptozotocin-induced hyperglycemic rats, but had no significant effect on serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL2C).
Liver protection: Dihydromyricetin has significant protective effects on hepatocytes carbon tetrachloride toxic injury, D2 galactosamine and lipopolysaccharide-induced liver injury in mice. Dihydromyricetin can protect the liver, accelerate the decomposition of acetaldehyde (ethanol metabolite) into non-toxic substances, reducing the damage to the liver cells. In addition, dihydromyricetin can improve hepatic cell injury caused by increased serum lactate dehydrogenase activity, inhibit the formation of hepatic M cell collagen fibers, which plays a hepatoprotective effect to reduce the damage of ethanol on the liver.
Antioxidant effect: 98% dihydromyricetin could significantly inhibit the formation of malondialdehyde (MDA) in myocardial homogenate, liver and brain homogenate, and the inhibition activity becomes stronger with higher purity of dihydromyricetin, 99% dihydromyricetin performs better on scavenging the DPPH free radicals. Dihydromyricetin can significantly inhibit the formation of MDA in oil, dihydromyricetin (60% ~ 90%) has strong anti-oxidant effect on animal oils and vegetable oils.
Anti-tumor effect: small molecules of dihydromyricetin have a strong anti-cancer effect. In vitro antitumor research found that dihydromyricetin can inhibit the growth of tumor blood vessels and regulate and enhance the cellular immunity.