There are two ways of cell death: necrosis and apoptosis or programmed death. The main goal of traditional tumor therapy is to use cytotoxic drugs or radiation to cause cell death. Apoptosis is a kind of gene-mediated suicide process, which is the opposite regulatory mechanism of mitosis in cell proliferation. It is also a protective mechanism for the body to instantly remove excessive damaged cells and pre-cancerous cells.
The genes involved in apoptosis include the anti-oncogenes P53, Bcl-2, myc and so on. Bcl-2 gene can inhibit cell apoptosis and promote cell growth; wild type P53 and myc genes can promote cell apoptosis and inhibit tumor growth. It seems to be a mutual adjustment between them.
Many anticancer drugs are known to have an effect of inducing apoptosis of tumor cells. In addition, it has also been found that many anti-tumor drugs that are not commonly used also have an effect of inducing apoptosis, such as ursolic acid.
Ginsenoside Rh2 is an exogenous differentiation inducer. Ginsenoside Rh2 can inhibit a variety of tumors by inducing differentiation and apoptosis, so that cancer cells not only undergo morphological differentiation, but also functionally change differentiation, and finally cause cancer cells to re-orient to normal cells, including genes. Many of the signs of expression are close to normal cells, or even completely converted into normal cells.
This phenomenon is called re-differentiation, that is, reversal. It has been confirmed by experiments that ginsenoside Rh2 can induce the reversal of cancer cells such as liver cancer, melanoma, teratoma and leukemia to normal cells. The main effects of ginsenoside Rh2 on tumor inhibition include the following:
Ginsenoside Rh2 is a natural active ingredient extracted from ginseng. It has been proved by many international authoritative experts to have good anti-tumor activity and inhibit the growth of tumor cancer cells. Ginsenoside Rh2 mainly kills tumor cells in proliferative phase, especially for S phase and M phase cells.
Ginsenoside Rh2 can effectively enhance the phagocytic function of monocyte macrophages and induce apoptosis of tumor cells.
The HK cell activity function of ginsenoside Rh2 induces differentiation of tumor cancer cells.
Ginsenoside Rh2 can reduce the toxicity of radiotherapy and chemotherapy by improving immunity, and effectively reduce the pain of radiotherapy and chemotherapy. Rh2 is a protective agent for various organ tissues including gastrointestinal tract.
It can effectively protect gastric mucosa, improve gastrointestinal function, increase appetite, and significantly reduce gastrointestinal adverse reactions caused by radiotherapy and chemotherapy.
In addition, many studies have shown that the effect is better chemotherapy drugs and Chinese ginsenoside Rh2 are used together. In “Ginsenoside Rh2 enhances paclitaxel-induced apoptosis in Hela cells”, Dr. Jiao Yulian indicated that ginsenoside Rh2 synergistically promoted paclitaxel-induced proliferation inhibition and apoptosis induction of Hela cells.
Ginsenoside Rh2 is a non-cytotoxic anti-tumor drug, which can effectively inhibit the growth and proliferation of various tumor cells, inhibiting the nucleic acid synthesis of tumor cells, inducing apoptosis and differentiation of tumor cells. And ginsenoside Rh2 can be improve the cellular immune function of the tumor-bearing body. In addition, ginsenoside Rh2 also has the advantages of anti-tumor metastasis, low toxicity, low tolerance and less side effects, and it increases the anti-tumor effect of other drugs with a promising application prospect.